草铵膦合成工艺的改进研究

An Improved Synthetic Process of Glufosinate-ammonium

对草铵膦的合成工艺进行改进。以γ-丁内酯和亚硝基正丁酯为原料,所得肟化产物,经过钯碳催化氢化成胺,氨基乙氧羰基保护得到(2-氧代四氢呋喃-3-基)氨基甲酸乙酯。该中间体开环氯化后与甲基亚磷酸二乙酯反应生成的膦酰化中间体,经酸化水解、氨化得到产物草铵膦。反应总收率为28.6%。相对于其他草铵膦合成路线,本路线具有污染较少,产率较高,反应条件比较温和等优点,具有一定的工业化潜力。

Improvement of synthesis process of glufosinate-ammonium was described in this paper.The target product was synthesized from 1,4-butyrolactone and butyl nitrite via oximation,deoxidization,amino protection,esterification,phosphorylation,hydrolysis.The total yield reached 28.6%.Compared with other processes of glufosinate-ammonium,this improved process has the advantages of less waste,high yield,warm reacting conditions.It is valuable to be used in industrial scale.