高危新生儿连续微量血糖监测的临床意义

The Clinical Significance of High-risk Newborns Continuous Glucose Monitoring Trace

目的探讨高危新生儿连续微量血糖监测指导围产期并发症治疗的临床意义及一年随访的结果分析。方法简单随机选择2014年2月—2016年2月于该院住院的高危新生儿200例,采用连续微量血糖测定(6 h、12 h、24 h、1 d、2 d、3 d),定义≤2 mmol/L为低血糖,分为两组:低血糖组(n=54),正常组(n=146),低血糖组给予对应治疗。将两组围产期并发症发生的差异及随访一年的资料进行比较。结果低血糖新生儿围产期并发症发生率为25.9%(14/54)高于正常对照组9.5%(14/146)(P<0.05);低血糖通常发生在并发症出现之前,血糖降低发生越快,持续时间越长,并发症越重。低血糖组的智力发育指数和运动发育指数显著低于正常组(MDI:65.4 vs 86.3,PDI:63.1 vs 87.2,P<0.05),差异有统计学意义。结论对危重新生儿进行连续微量血糖监测具有重要意义,可指导围产期并发症的治疗。

Objective To investigate the risk neonates trace continuous glucose monitoring to guide treatment of perinatal complications and clinical significance of one year follow-up analysis of the results.Methods February 2014 to February2016 200 cases in our hospital risk neonates, continuous trace glucose measurement(6 h, 12 h, 24 h, 1 d, 2 d, 3 d), defined≤2mmol/L is hypoglycemic, divided into two groups: low glucose group(n = 54), the normal group(n = 146), corresponding to the treatment group received hypoglycemia. The difference between the two groups of perinatal complications and followup year data for comparison. Results The perinatal complications of neonatal hypoglycemia was 25.9%(14/54)higher than the normal control group 9.5%(14/146)(P <0.05); hypoglycemia usually occurs before complications arise, the faster the blood glucose reduced,the longer the duration lasted, the heavier the complications were. Mental development index and psychomotor development index hypoglycemia was significantly lower than the normal group, the difference was statistically significant(MDI:65.4 vs 86.3, PDI:63.1 vs 87.2,P<0.05). Conclusion The critically ill newborns continuous glucose monitoring trace of great significance to guide the treatment of perinatal complications.