急性心力衰竭合并感染患者降钙素原及C反应蛋白水平变化的临床意义

The Clinical Significance of Procalcitonin and C-reactive Protein Level Change in Patients with Acute Heart Failure Co-infection

目的探讨在急性心力衰竭合并感染患者中血清降钙素原(PCT)及C反应蛋白(CRP)水平变化的临床意义。方法整群选择2014年1月—2015年12月于该院就诊的急性心力衰竭患者共129例,分为心力衰竭合并感染组71例,单纯心力衰竭组58例,另选择健康体检者30名为正常对照组。检测所有受试者血清中降钙素原及C反应蛋白水平,对检测结果进行统计学处理并分析。结果心力衰竭合并感染组PCT及CRP明显高于单纯心力衰竭组及正常对照组(P<0.01);而单纯心力衰竭组PCT及CRP明显高于正常对照组(P<0.01)。PCT及CRP与合并感染均成正相关。PCT的最佳诊断界值为0.71 ng/m L,敏感度为75.9%,特异度为89.5%;CRP的最佳诊断界值为38.3 mg/L,敏感度为87.1%,特异度为69.2%。结论联合检测PCT及CRP可为急性心衰合并感染患者的早期诊断、早期治疗提供有力证据。

Objective To evaluate The clinical significance of procalcitonin(PCT) and C-reactive protein(CRP) level change in Patients with acute heart failure co-infection. Methods Group selection 129 cases patients with acute heart failure from January 2014 to December 2015 in our hospital were collected.The patients were divided into acute heart failure combined infection group and merely acute heart failure group.30 cases healthy controls were selected as control group.The serum procalcitonin and C-reactive protein of all the subjects were detected,and the results were analyzed statistically.Results The levels of PCT and CRP in heart failure combined infection group was obviously higher than that of merely heart failure group and normal control group(P < 0.01). And the levels of PCT and CRP in merely heart failure group was obviously higher than that of normal control group(P < 0.01). In patients with acute heart failure,PCT and CRP with infection is Positive correlation to both relationship. The best truncation point of PCT was 0.71 ng/m L,the sensitivity was 75.9% and the specificity was 89.5%.The best truncation point of CRP was 38.3 mg/L,the sensitivity was 87.1% and the specificity was69.2%. Conclusion The combined detection of PCT and CRP provide favorable evidence for early diagnosis and early treatment of patients with acute heart failure combined infection.