玻璃酸钠联合重组牛碱性成纤维细胞生长因子滴眼液治疗142例干眼症并角膜上皮损伤的临床效果分析

Fibroblast Growth Factor Drops of Eye Drops Treatment of 142 Cases of Dry Eye and Corneal Epithelial Injury and the Clinical Effect of Sodium Hyaluronate Combined with Recombinant Bovine Basic Fibroblast

目的探究玻璃酸钠联合重组牛碱性成纤维细胞生长因子(r-b FGF)滴眼液治疗142例干眼症并角膜上皮损伤的临床效果。方法整群选取2014年2月—2016年2月于该院诊治的284例(284只眼)干眼症并角膜上皮损伤患者采用随机数字表法均分为两组,每组142例。对照组给予玻璃酸钠滴眼液治疗,观察组给予玻璃酸钠联合r-b FGF滴眼液治疗。比较两组患者裂隙灯下泪膜破裂时间(BUT)、泪液分泌试验(SIt)情况;比较两组患者临床疗效。结果治疗后观察组SIt(7.53±0.89)mm、BUT(6.27±1.23)s显著高于治疗前(4.46±0.94)mm、(4.06±0.82)s及对照组(6.03±0.72)mm、(5.24±1.11)s(P<0.05)。治疗后观察组总有效率为94.37%较对照组71.83%显著较高,差异有统计学意义(P<0.05)。结论玻璃酸钠联合r-b FGF滴眼液治疗干眼症并角膜上皮损伤患者可显著延长BUT、改善泪液分泌情况,其临床疗效尤佳。

Objective Study of sodium hyaluronate and recombinant bovine basic fibroblast growth factor(b FGF) eyedrops in the treatment of 142 cases of dry eye and corneal epithelial injury and the clinical effect of. Methods Group selection from February 2014 to February 2016 in our hospital for treatment of 284(284 eyes) dry eye and corneal epithelial injury in patients with the random number table were divided randomly into two groups,Each group of 142 cases. The control group was given Sodium Hyaluronate Eye Drops treatment, the observation group was treated with sodium hyaluronate combined with r-b FGF eye drops. Compared two groups of patients with slit lamp tear break-up time(BUT), tear secretion test(SIt),compared two groups of patients with clinical curative effect. Results After treatment, the observation group SIt(7.53 ± 0.89)mm, BUT(6.27 ± 1.23) s was significantly higher than before treatment(4.46±0.94) mm,(4.06 ± 0.82) s and control group(6.03±0.72) mm,(5.24±1.11) s(P < 0.05). After treatment, the total effective rate of the observation group was 94.37% compared with the control group(71.83%), the difference was statistically significant(P < 0.05).Conclusion Glass acid sodium combined with b FGF eye drops in treatment of dry eye and corneal epithelial injury patients can be significantly prolonged break-up time(but), improving the tear secretion and its clinical effect is a plus.