复方樟柳碱两种注射方法治疗视网膜中央静脉阻塞的比较

Comparison of Clinic Effect on Central Retinal Vein Occlusion with Compound Anisodine by Two Kinds of Injection

目的比较颞浅动脉旁皮下注射和球后注射复方樟柳碱治疗视网膜中央静脉阻塞的临床效果和护理措施。方法方便选取2015年1月—2016年6月该院眼科门诊确诊的73例缺血性视网膜中央静脉阻塞患者在激光治疗的同时应用复方樟柳碱辅助治疗,按随机数字表分为2组,36例采用颞浅动脉旁皮下注射,37例采用球后注射。对两组的病例作视力、FFA检查、注射NRS评分、不良反应的对比。结果治疗后颞浅动脉旁皮下注射组NRS评分较球后注射组低,比较差异有统计学意义(P<0.05),球后注射组治疗后少数的患者出现眼球活动受限、暂时性上睑下垂、一过性瞳孔散大等改变,皮下注射组未出现不良反应。两组视力及FFA检查差异无统计学意义(P>0.05)。结论颞浅动脉皮下注射复方樟柳碱治疗缺血性视网膜中央静脉阻塞,与球后注射给药有相当的疗效,且患者的疼痛程度低,不良反应较少。

Objective Comparison of clinical effect and nursing experience was injected subcutaneously around superficial temporal artery and retrobulbar injection of compound anisodine in the treatment of central retinal vein occlusion. Methods Convenient selection January 2015 to June 2016 in our hospital outpatient diagnosis of 73 cases of ischemic central retinal vein obstruction patients in laser treatment and application of compound anisodine adjuvant therapy, according to the random number table is divided into 2 groups and 36 patients with para temporal superficial artery subcutaneous injection, 37 cases with retrobulbar injection. Visual acuity, FFA examination, NRS score and adverse reaction were compared between the two groups. Results After treatment, numeric rating scales of the patients with Compound Anisodine subcutaneous injection near the temporal superficial artery were significantly lower than the retrobulbar injection group(P<0.05). Moreover some of the eyes after conduct of retrobulbar injection show the signs as limitation of motion 、blephroptosis and mydriasis.while patients of subcutaneous injection group appear no adverse reaction. The visual acuity and FFA of subcutaneous injection group and retrobulbar injection group have no statistics difference(P >0.05). Conclusion Subcutaneous Injection near the temporal superficial artery with Compound Anisodine has the same therapeutic effect as retrobulbar injection on CRVO, though with lower pain degree and the fewer side reactions.