OGT在食管癌中的表达及其与临床预后的关系

Expression of OGT in esophageal cancer and its relationship with clinical outcome

目的探讨O-GIc NAc转移酶(O-Gic NAc transferase,OGT)在食管癌组织中的表达情况及其与预后的关系。方法收集66例食管癌组织标本及其对应癌旁组织标本,利用免疫组化法测定OGT蛋白的表达,并与患者的临床资料相结合。比较OGT表达与年龄、性别、淋巴结转移、肿瘤分化和TNM分期之间的关系,并结合随访资料分析OGT表达和临床预后的关系。结果 66个肿瘤标本中,51例(77.27%)阳性表达,15例(22.73%)阴性表达。癌旁正常组织中OGT阳性表达率为21.21%(14/66)。OGT的表达还与TNM分期、病理分化相关(P<0.001),与年龄、性别和淋巴结转移无关(P>0.05)。OGT阳性表达和阴性表达食管癌患者的3年生存率分别为43.7%和64.2%,两者比较差异有统计学意义(P=0.003)。结论OGT可能被用作预测食管癌预后的良好指标。

Objective To investigate the expression of O-GIc NAc transferase（ OGT） in the esophageal cancer and its relationship with prognosis. Methods Esophageal cancer tissues and the corresponding paracancerous tissues were collected from 66 esophageal cancer patients. The expression of OGT was measured by immunohistochemistry and the correlation between OGT expression and clinicopathological parameters and prognosis were analyzed. Results Of the 66 tumor specimens,51（ 77. 27%） were positive and 15（ 22. 73%） were negative. The positive rate of OGT was 21. 21%（ 14 /66） in paracancerous tissues. The overexpression of OGT was also positively associated with TNM stage and differentiation（ P〈0. 001）. However,it was not significantly associated with age,gender and lymph node metastasis（ P〈0. 05）. The 3-year survival rate in patients with high OGT expression was lower than that with low expression（ 43. 7%vs 64. 2%,P = 0. 003）. Conclusion OGT may be used as a novel biomarker for predicting the prognosis of esophageal cancer.