HE4和CA125在卵巢肿瘤中的应用价值

The application value of tumor markers HE4 and CA125 in ovarian tumor

目的通过卵巢肿瘤患者血清人附睾蛋白4（HE4）及糖类抗原125（CA125）的检测,建立一种预测卵巢恶性肿瘤的简便有效方法。方法采用罗氏电化学发光法检测2013年1月~2014年12月我院453例女性血清HE4、CA125水平,其中卵巢恶性肿瘤患者80例,卵巢良性肿瘤患者373例（包括卵巢子宫内膜异位囊肿135例,卵巢畸胎瘤116例,黏液性和浆液性囊腺瘤45例,卵巢单纯性囊肿51例,黄体囊肿26例）。对所有结果进行统计学分析。结果血清HE4水平在不同卵巢良性肿瘤患者各组间两两比较,差异无统计学意义（P〉0.05）;而血清CA125水平,卵巢子宫内膜异位囊肿组高于其他组,差异有统计学意义（P〈0.05）,其余各组间两两比较,差异无统计学意义（P〉0.05）。若以良性卵巢肿瘤为对照,在血清HE4的cut-off值为126.2 pmol/L时,卵巢恶性肿瘤患者的临床诊断灵敏度为72.5%。结论 HE4及CA125是临床辅助卵巢肿瘤诊断的较好指标。

Objective To establish a simple and effective method of predicting ovarian malignant tumor by the detection of serum human epididymis protein 4（HE4） and carbohydrate antigen 125（CA125） of patients with ovarian tumor.Methods Serum HE4 and CA125 levels of 453 patients with ovarian tumor in our hospital from January 2013 to December 2014 were determined by Roche electrochemical luminescence method.Among them,80 patients with ovarian malignant tumor,373 patients with ovarian benign tumors（including 135 cases of ovarian endometriosis cyst,116 cases of ovarian teratoma,45 cases of mucous and serous cystadenoma,51 cases of ovarian simple cyst and 26 cases of corpus luteum cyst）.All the results were statistically analysed.Results Comparison of serum HE4 levels between patients with ovarian benign tumor,there was no statistically significant difference（P〉0.05）;serum CA125 level of ovarian endometriosis cyst group was higher than that of other groups,the difference was statistically significant（P0.05）, Comparison between the rest of the group,there was no statistically significant difference（P〉0.05）.If compared with benign ovarian tumors,serum HE4 cut-off value was 126.2 pmol/L,the clinical diagnosis sensitivity in patients with ovarian malignant tumor was 72.5%.Conclusion HE4 and CA125 are better clinical auxiliary diagnosis indicator of ovarian tumor.