直肠癌术前同步放化疗不同放疗分割方式的临床研究

Clinical research of different radiotherapy fractionated methods of preoperative concurrent radiotherapy and chemotherapy for rectal cancer

目的探讨直肠癌术前同步放化疗不同放疗分割方式的临床疗效。方法选取2015年6月~2016年8月我院收治的60例中低位Ⅱ~Ⅲ期直肠癌患者为研究对象,按照随机数表法分为观察组和对照组,每组各30例。观察组采取改良短程放化疗,对照组采用常规分割放化疗,比较两组患者直肠分段、乙状结肠襻式造瘘术等一般资料情况,肿瘤降期率及不良反应。结果观察组降期率为30.00%（9/30）,小于对照组的68.00%（20/30）（P〈0.05）;观察组毒副作用及不良反应总发生率为30.00%（9/30）,小于对照组的50.00%（15/30）,差异无统计学意义（P〉0.05）。结论给予直肠癌患者术前同步化疗改良短程式与常规分割化疗均可行,根据不同的患者情况进行不同的放疗方式,减少局部复发,提高疗效。

Objective To explore the clinical effects of different radiotherapy fractionated methods of preoperative concurrent radiotherapy and chemotherapy for rectal cancer.Methods 60 patients with middle and low Ⅱ-Ⅲ stage rectal cancer in our hospital from June 2015 to August 2016 were selected as study objects and divided into observation group and control group by random number table,with 30 cases in each group.Patients in the observation group were used modified short course radiotherapy and chemotherapy,and patients in the control group were used conventional fractionated radiotherapy and chemotherapy.General information of rectum segmentation and sigmoid loop colostomy,tumor drop period rates and adverse effects of patients in two groups were compared.Results The drop period rate in the observation group was 30.00%（9/30）,lower than 68.00%（20/30） in the control group（P〈0.05）;total incidence rate of toxic and side effect and adverse reaction in the observation group was 30.00%（9/30）,lower than 50.00%（15/30） in the control group,the difference between two groups was not statistically significant（P〉0.05）.Conclusion Both of preoperative concurrent chemotherapy modified short course and fractionated chemotherapy are suitable for rectal cancer patients.Different ways of radiotherapy are used according to different patients,which can reduce the incidence of local recurrence and enhance effects.