抑郁症患者抑郁水平与其执行功能、反刍思维间的关系分析

Relationship among depression level, executive function and rumination in patients with depression

目的：探讨抑郁症患者的抑郁水平与其执行功能、反刍思维之间的关系。方法选取103例抑郁症患者,采用一般资料问卷、执行功能行为评定量表（ BRIEF-A）、反刍反应量表（ RRS）和贝克抑郁量表（ BDI-II）评估患者的抑郁严重程度、生态学执行功能、反刍思维倾向等,分析抑郁情绪与反刍思维、执行功能的关系。结果本组患者抑郁症状得分平均（25.12±12.85）分,反刍思维量表得分平均（48.84±15.46）分,执行功能行为评定量表总分平均（119.40±28.55）分。抑郁量表总分与反刍思维各维度和执行功能总分呈正相关,有统计学意义（ r值分别为0.424,0.603,0.469,0.565；P〈0.01）。回归分析显示,反刍思维对执行功能和抑郁存在部分中介作用,中介效应占总效应的39.4％。结论抑郁与反刍思维呈正相关,与执行功能的受损程度呈正相关,反刍思维与执行功能的受损程度呈正相关,反刍思维在执行功能与抑郁的关系中起部分中介作用。

Objective To explore the relationship among depression level, executive function and rumination in patients with depression. Methods We selected 103 patients with depression. And then, we investigated them about the depression level, ecological executive function, dispositions and so on with the general condition questionnaire, behavior rating inventory of executive function-adult version （ BRIEF-A ） , ruminative responses scale （ RRS） and Beck depression rating scale （ BDI-II） and analyzed the relationship among depressive emotion, executive function and rumination.Results The score of the depressive symptoms, RRS and BRIEF-A was （25.12±12.85）,（48.84±15.46）,（119.40±28.55）. The total score of BDI-II had positive correlations with the score of all dimensions of RRS and the total score of BRIEF-A with significant differences （ r=0.424,0.603,0.469, 0.565;P〈0.01）. Regression analysis showed that rumination had a partly mediating effect （accounting for 39.4%in gross effect） between executive function and depression.Conclusions Depression has positive correlations with rumination and extent of damage to executive function. Moreover, rumination has a positive correlation with the extent of damage to executive function. Besides, rumination has a partly mediating effect in the relationship between executive function and depression.