天然药物化学史话:“四大光谱”在天然产物结构鉴定中的应用

Historical story on natural medicine chemistry: Application of UV, IR, MS, and NMR spectra in structure elucidation of natural products

天然产物化学研究在药物研发中起着非常重要的作用,结构研究又是天然产物化学研究中最重要的工作之一。在天然药物化学史话系列文章的基础上,对在天然产物结构研究中起绝对主导作用的"四大光谱"分析技术,即红外光谱、紫外光谱、质谱、核磁共振波谱在天然产物结构鉴定中的应用历史进行回顾与总结,并对其发展前景进行展望。

The study on natural product chemistry plays an important role in drug development, and the structure elucidation is one of the vital tasks in the natural product chemistry research. This paper summarized the application ofUV, IR, MS, and NMR spectra in the structure elucidation of natural products with 123 papers cited. This article is one of the series of historical stories on natural product chemistry published in this journal, which are reviewed and summerized. The developing future is looked forward.