白藜芦醇对大鼠代谢网络通量的影响

Effect of Resveratrol on Metabolic Network Flux in Rats

本研究设置了对照组以及白藜芦醇低、中、高3个剂量(2、20、200 mg/kg)实验组,每组各6只雄性大鼠,对灌胃后的大鼠建立代谢网络模型,进行乳酸代谢网络通量的研究。结果表明:在给大鼠喂食2 mg/kg的白藜芦醇时,机体分解代谢降低,但当白藜芦醇的剂量为20 mg/kg时,机体分解代谢增加,当白藜芦醇剂量为200 mg/kg时,机体分解代谢增加趋势更为明显。在白藜芦醇剂量为2 mg/kg时,机体分解代谢最低,低剂量的白藜芦醇可能有助于现代文明病的预防和治疗。当剂量达到200 mg/kg时,机体分解代谢明显增强,说明它可能会对机体造成毒副作用。显然,白藜芦醇只能在一定的剂量范围内发挥保健作用。

A large number of studies have shown that lactic acid metabolism flux can be used to quantitatively describethe state of the body in the condition of normal life. When it is reduced, the body is in good shape; in contrast, when it isincreased, the body is in the state of inflammation or detoxification. In recent years, a number of reports have demonstratedthe prevention of diseases of modern civilization by resveratrol and it is evident that this effect is closely related to lactatemetabolism flux. However, studies on its metabolism in the body have rarely been reported. In the present study, one controlgroup and three resveratrol treatment groups at low, medium and high doses （2, 20 and 200 mg/kg）, each consisting of 6 malerats were designed. After the rats were administered by gavage, a metabolic network model for metabolic flux analysis wasestablished. The results showed that the body catabolism was reduced by administration of 2 mg/kg of resveratrol, but it wasincreased dose-dependently when the dose was over 20 mg/kg. Based on these results, resveratrol at 2 mg/kg could resultin the lowest body catabolism, suggesting that it can help prevent and treat diseases of modern civilization. As it resulted ina significant increase in the body catabolism, resveratrol at 200 mg/kg could cause toxic side effects to the body. Therefore,resveratrol can play a role in protecting the body against diseases only in a certain dose range.