复杂性状遗传CC小鼠的特点及实际应用中的提示

The character of Collaborative Cross mice and tips for its application

实验动物为生命科学研究提供支持,特别是小鼠,因其遗传、免疫等信息积累丰富而应用广泛。后基因组时代,为了研究人类以及动物的基因组信息,人们建立了多种转基因、基因敲除小鼠模型以研究某一单基因功能;然而人类大部分疾病并非单基因疾病,除受外界环境影响,一般受多遗传因素控制。生命科学领域的多基因相关的复杂性状研究向实验动物提出了新的要求。因此科学家提出了建立协同杂交小鼠(CC小鼠)资源的计划。本文将对CC小鼠出现的背景、特点及应用中需要考虑的问题做一概述。

Laboratory animals support the life science research. Based on their clear genetic,immune background,mice have been widely used. In the Post-genomics era,a great deal of genetic engineering mouse models,including those transgenic mice and gene targeted mice had been developed to study some a specific gene. However,most human diseases are not controlled by a single gene; besides the environmental factors,multiple genetic factors can influence the development of human diseases. The complex multi-gene traits research in life science put forward new challenges to the laboratory animals. To meet this challenge,scientists have proposed to develop a new mouse resource called the Collaborative Cross（ CC） mice. This paper will review the background and character of CC mice,and gives some suggestions for its application.