糖尿病研究中的动物模型进展

Animal models in diabetes mellitus research

虽然糖尿病的研究不断有新的进展,诊断方法和治疗手段不断更新,但其危害并没有明显降低,反而呈现逐年加重的趋势。为了更深入、全面地揭示糖尿病机制,研发更有效、可靠、无低血糖风险的药物必须清楚了解相应的疾病模型。该文就糖尿病动物模型的种类,建模方法,优缺点,适用范围等进行综合评述,旨在为研究者选择合适的动物模型提供参考。

In spite of much progress on its mechanism,diagnosis and treatment,diabetes mellitus remains a public health challenge. The harm of diabetes is not significantly reduced,instead shows an increasing tendency year by year. To achieve an in-depth and comprehensive understanding of the underlying mechanism,and to develop efficacious,stable and hypoglycemia-risk free drugs,it is crucial to gain more knowledge about diabetes from animal models. In this review,the types of diabetes animal models,modeling methods,the advantages and disadvantages,their applicable scope are discussed aiming to provide a reference for researchers to choose appropriate animal models.