急性心肌梗死病人血清BNP、Hcy、hs-CRP与甲状腺激素水平相关性

CORRELATION OF SERUM BNP,HCY,HS-CRP AND THYROID HORMONE LEVELS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

目的探讨急性心肌梗死病人血清B型脑钠肽（BNP）、同型半胱氨酸（Hcy）、超敏C反应蛋白（hsCRP）与甲状腺激素水平相关性。方法选择2012年6月—2015年6月在我院接受治疗的80例急性心肌梗死病人作为观察组,另随机选择同期在我院进行体检且与观察组年龄相仿的健康体检者80例作为对照组。采用酶联免疫分析法检测两组血清BNP、Hcy水平,免疫比浊法检测血清hs-CRP水平,化学发光免疫法检测甲状腺激素水平,并对BNP、Hcy、hs-CRP与甲状腺激素水平进行相关性分析。结果观察组病人血清BNP、Hcy、hs-CRP、游离三碘甲状腺原氨酸（FT3）及游离甲状腺素（FT4）水平均显著高于对照组（t=4.326~44.120,P〈0.05）;而两组促甲状腺激素（TSH）水平差异无统计学意义（P〉0.05）。血清BNP、Hcy、hs-CRP水平均与FT3、FT4水平呈正相关（r=0.375~0.573,P〈0.05）。结论急性心肌梗死病人血清BNP、Hcy、hs-CRP、FT3及FT4水平显著增高,血清BNP、Hcy、hs-CRP均与FT3、FT4水平呈正相关,以上指标联合检测可用于急性心肌梗死病情的评估。

Objective To explore the correlation of serum levels of BNP,Hcy,hs-CRP and thyroid hormone in patients with acute myocardial infarction（AMI）. Methods Eighty AMI patients treated-during the period from June 2012 to June 2015-in our hospital were selected to be served as the observation group,another 80 healthy people of similar age were selected in random served as the control group.Employing enzyme immunoassay technique,serum BNP and Hcy in both groups were detected,immunoturbidimetry was used to measure serum hs-CRP,and thyroid hormone level was detected using chemoluminescence test.A correlation analysis of BNP,Hcy,hs-CRP and thyroid hormone was carried out. Results Serum levels of BNP,Hcy,hs-CRP,FT3 and FT4 in the patients were notably higher than that in the healthy controls（t=4.326-44.120,P〈0.05）,and the difference in TSH（thyroid stimulating hormone）between the two groups was not statistically significant（P〉0.05）.Serum BNP,Hcy and hs-CRP were positively correlated with levels of FT3 and FT4（r=0.375-0.573,P〈0.05）. Conclusion In this study,serum levels of BNP,Hcy,hs-CRP,FT3 and FT4 in patients with acute myocardial infarction notably elevated and BNP,Hcy,hsCRP were positively correlated with FT3 and FT4.A combined detection of the above indexes can be used for assessing the state of the disease.