腹腔镜联合GnRH-α药物治疗子宫内膜异位症的疗效观察

Curative Effect of Laparoscopic Combined GnRH-α in the Treatment of Endometriosis

目的:探究与分析腹腔镜联合促性腺激素释放激素激动剂(Gn RH-α)药物治疗子宫内膜异位症的疗效。方法:选取2013年11月-2014年1月本院收治的子宫内膜异位症不孕患者120例作为研究对象,采取随机数字表法将其分为试验组和对照组,每组60例。两组患者均行腹腔镜手术,试验组于术后3 d肌肉注射Gn RH-α,对照组不作任何药物辅助治疗,观察并比较两组治疗前后生殖激素水平、治疗效果和受孕情况。结果:试验组治疗后卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)明显低于治疗前,试验组低于对照组,比较差异均有统计学意义(P<0.05);试验组总有效率高于对照组,复发率低于对照组,试验组治疗1、2年后受孕率均明显高于对照组,比较差异均有统计学意义(P<0.05)。结论:对子宫内膜异位症患者进行腹腔镜手术后联合使用Gn RH-α药物可以对患者体内FSH、LH及E2水平产生调节作用,并且提高患者的受孕率,减少复发,在一定程度上提高了患者的生活质量,值得临床推广。

Objective： To investigate and analyze the clinical efficacy of laparoscopic surgery combined with GnRH-ct in the treatment of endometriosis.Method： From November 2013 to January 2014, 120 cases of endometriosis ihfertility patients in our hospital were selected as the research objects, they were divided into the experimental group and the control group according to the random number table method, each group had 60 cases.Two groups were performed laparoscopic surgery, the experimental group treated with intramuscular injection of GnRH- α postoperative 3 d and the control group did not make any drug adjuvant therapy, the reproductive hormone levels, treatment effect and pregnancy before and after treatment of two groups were observed and analyzed.Result： After treatment, follicle stimulating hormone （ FSH ）, luteinizing hormone （ LH ） and estradiol （ E2 ） of the experiment group were significantly lower than those of before treatment, the experimental group was lower than the control group, the differences were statistically significant （P〈0.05） .The total effective rate of the experimental group was higher than that of the control group, the recurrence rate was lower than that of the control group, the pregnancy rate of the experimental group was significantly higher than that of the control group after 1 and 2 years, the differences were statistically significant （ P〈0.05 ） .Conclusion： For endometriosis patients, the treatment combining with laparoscopic surgery and GnRH-α can significantly improve FSH, LH, and E2 levels, enable to increase the conception rate and reduce the complications, it improve the quality of life of patients to a certain extent and is worthy of clinical promotion.