摘要
该文介绍了一种新型模拟心脏血流形态的药物释放装置,利用该装置来模拟人体生理环境下药物洗脱支架中药物的释放。实验结果表明,该装置测定释放度的结果满足试验规律,具有一定的体内外相关性,从而说明本装置具备作为体外释放度测定方法的价值。
A novel drug delivery device simulating the cardiovascular bloodfl ow pattern was introduced. The device was used to simulate the in vivo drug release in the drug-eluting stents. The results regarding the drug release rate were subject to the pattern from in vivo measurement. Therefore, the device was validated as a measurement method for in vivo drug release rate.
出处
《中国医疗器械杂志》
2016年第5期322-325,共4页
Chinese Journal of Medical Instrumentation
基金
上海市科委课题(13441902600)
关键词
释放装置
药物洗脱支架
雷帕霉素
simulating dissolution device
drug-eluting stent
rapamycin
