虾青素软胶囊遗传毒性研究

Study on the genetic toxicity of Astaxanthin Soft Capsules

目的研究虾青素软胶囊的遗传毒性。方法采用鼠伤寒沙门氏菌回复突变试验(Ames试验)、小鼠骨髓细胞微核试验和小鼠精子畸形试验等实验方法对虾青素软胶囊的遗传毒性进行研究。结果虾青素软胶囊鼠伤寒沙门氏菌回复突变试验受试物各剂量组回变菌落数均未超过自发回变组回变菌落数的2倍,结果为阴性;小鼠骨髓细胞微核试验和小鼠精子畸形试验受试物各剂量组与空白对照组比较,微核率及精子畸变率无明显差异(P>0.05),实验结果为阴性。结论在本实验条件下,虾青素无遗传毒性。

Objective To evaluate the potential genetic toxicity of Astaxanthin Soft Capsules.Methods The potential genetic toxicity of Astaxanthin Soft Capsules was studied by Salmonella typhimurium reverse mutation assay （ Ames test ） , bone marrow cell test and mice sperm abnormality test.Results In Ames test, the number of revertant colonies of test sam- ple group was no more than the twice of spontaneously revertant colonies group,the test result represented negative.In bone marrow cell test and mice sperm abnormality test, the proportion of micronuclei and the rate of sperm abnormality have no significant difference between test sample group and blank control group （P〉0.05） ,The results were also negative.Conclu- sion The genetic toxicity of astaxanthin was not showed in this study.