糖皮质激素与特布他林联合治疗慢性阻塞性肺疾病急性加重期的临床分析

Clinical analysis of glucocorticoid combined with Terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease

目的探讨糖皮质激素与特布他林联合治疗慢性阻塞性肺疾病急性加重期的临床效果。方法选取我院2013年6月~2015年6月收治的48例慢性阻塞性肺疾病患者作为研究对象,根据治疗方法不同分为实验组和对照组,各24例。对照组采用特布他林治疗,实验组在对照组的基础上加用糖皮质激素治疗,比较两组的治疗效果、氧分压（Pa O2）和二氧化碳分压（Pa CO2）变化及不良反应发生率。结果实验组的治疗总有效率为96%,显著高于对照组的70%,差异有统计学意义（P〈0.05）。实验组治疗后的Pa O2水平高于对照组,Pa CO2水平低于对照组,差异有统计学意义（P〈0.05）。实验组的不良反应发生率为4.2%,显著低于对照组的25.0%,差异有统计学意义（P〈0.05）。结论糖皮质激素与特布他林联合治疗慢性阻塞性肺疾病急性加重期的临床效果较好,不仅可以改善Pa O2及Pa CO2水平,降低不良反应发生率,而且能够提高患者的生存质量,值得临床推广应用。

Objective To explore the clinical effect of glucocorticoids combined with Terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease（COPD）.Methods 48 cases of COPD in our hospital from June 2013 to June 2015 were selected and divided into the experimental group and the control group according to the different treatment methods,24 cases in each group.The control group was treated with Terbutaline,the experimental group was treated with glucocorticoids on the basis of the control group.The treatment effect,oxygen partial pressure（Pa O2）,carbon dioxide partial pressure（Pa CO2） and the incidence rate of adverse reaction was compared between the two groups.Results The total effective rate of the experimental group was 96%,which was higher than 70% of the control group,with significant difference（P〈0.05）.The level of Pa O2 in the experimental group after treatment was higher than that in the control group,the level of Pa CO2 in the experimental group after treatment was lower than that of the control group,with significant difference（P〈0.05）.The incidence rate of adverse reactions in the experimental group was4.2%,which was lower than 25.0% in the control group,with significant difference（P〈0.05）.Conclusion Clinical effect of glucocorticoid combined with Terbutaline in the treatment of acute exacerbation of COPD is better,which can not only improve the level of Pa O2 and Pa CO2,reduce the incidence rate of adverse reaction,but also can improve the quality of life of patients,it is worthy of clinical promotion and application.