无线食管pH胶囊在咽喉反流诊断中的价值

The value of wireless pH capsule monitoring in the diagnosis of laryngopharyngeal reflux

目的探讨无线食管pH胶囊在咽喉反流诊断中的应用价值,以及胃食管反流病与咽喉反流的相关性。方法对12例有咽喉反流症状、咽喉反流症状指数量表(RSI)大于13分的的患者(LPR组)及12例健康志愿者(对照组),行咽喉反流症状指数量表(RSI)评分,再进行食管双pH胶囊监测48 h。监测期间记录饮食、睡眠、活动、服药等情况及不适症状,比较两组食管上下段反流的监测情况,并对胃食管反流指标及咽喉反流指标进行相关性分析。结果 LPR组pH胶囊监测检出的平均咽喉反流次数、食管下段的DeMeester评分(DMS)高于对照组,与RSI评分相符,差异有统计学意义(P<0.05)。LPR组咽喉反流次数与DMS显著相关。监测过程中未出现严重的不良反应。结论无线食管pH胶囊可用于咽喉反流的pH监测及诊断,有良好的准确性、耐受性、安全性。

Objective To investigate the correlation between gastroesophageal reflux and laryngopharyngeal reflux（ LPR） and the clincal value of wireless pH capsule monitoring in the diagnosis of LPR. Methods Tweleve patients with LPR symptoms who scored more than 13 in reflux symptoms index （ RSI） test and tweleve healthy volunteers were recruited. They were required to receive RSI test and 48-hour dual wireless pH monitoring. The details of meals, sleep, activities, and discomfort were recorded. The acid exposure and the correlation of proximal and distal esophageal were analyzed. Results The LPR episodes and DMS in LPR patients were significantly higher than that in healthy volunteer group （ P 〈0. 05 ） , in coincidence with the RSI scores. The LPR episodes were correlated with DMS in LPR patients significantly. There were not any severe side effects during monitoring. Conclusion Wireless pH capsule is effective in pH monitoring in laryngopharyngeal reflux with high accuracy,safety and tolerance.