奥美拉唑与泮托拉唑治疗消化道溃疡出血的成本-效果分析

Cost-effect analysis of omeprazole and pantoprazole for treating peptic ulcer hemorrhage

目的探讨奥美拉唑与泮托拉唑治疗消化道溃疡出血的成本与效果。方法选取该院消化内科2013年3月至2015年10月收治的80例消化道溃疡出血患者进行分析,将其分为对照组和观察组,各40例。对照组在常规治疗基础上加用奥美拉唑;观察组在常规治疗基础上给予泮托拉唑静脉滴注。对比分析两组患者住院时间、出血量、止血时间、治疗前后血常规指标变化、治疗效果、并发症发生率及每天治疗成本。结果对照组患者住院时间、出血量及止血时间均高于观察组,且血红蛋白水平、红细胞计数、血小板计数及血细胞比容改善水平均低于观察组,差异均有统计学意义(P<0.05);对照组患者治疗有效率(92.5%,37/40)与观察组(95.0%,38/40)比较,差异无统计学意义(P>0.05);但对照组患者每天治疗成本与并发症发生率均高于观察组,差异均有统计学意义(P<0.05)。结论应用奥美拉唑与泮托拉唑治疗消化道溃疡均具有一定疗效,但泮托拉唑治疗成本与出血量均低于奥美拉唑。

Objective To study the cost and effect of omeprazole and pantoprazole for treating peptic ulcer hemorrhage. Methods Eighty cases of peptic ulcer hemorrhage in the gastroenterology department of our hospital from March 2013 to October 2015 were selected for conducting analysis and divided into the control group and observation group,40 cases in each group. The control group was added with omeprazole based on the conventional treatment,while the observation group were given pantoprazole by intravenous drip on the basis of routine therapy. The hospital stays, bleeding amount, hemostatic time, changes of blood routine indexes before and after treatment, treatment effect, incidence of complications and daily treatment cost were compared between the two groups. Results The hospital stays, bleeding amount and hemostatic time of the control group were higher than those of the observation group, moreover the improvement levels of hemoglobin level, red blood cell count, platelet count and improving degree of blood cells hematocrit were lower than those in the observation group ,the differences were statistically significant （P〈0.05） ;the curative effect rate had no statistical difference between the control group and the observation group[92.5% （37/40） vs. 95.0% （38/40）,P〉0.05） ;but the daily treatment costs and the occurrence rate of complications in the control group were higher than those in the observation group ,the differences were statistically significant（P〈0.05 ）. Conclusion Using omeprazole and pantoprazole in treating peptic ulcer all posses some effect, but the treatment cost and bleeding amount of pantoprazole are lower than those of omeprazole.