银杏达莫注射液治疗急性脑梗死的Meta分析

Meta-analysis of Ginkgo Leaf Extract and Diphyridamole Injection in the Treatment of Acute Cerebral Infarction(ACI)

目的:系统评价银杏达莫注射液治疗急性脑梗死的疗效及安全性。方法:收集国内外与银杏达莫注射液治疗急性脑梗死相关的临床随机对照综述文献,应用Jadad评分法进行质量评价并提取有效数据进行Meta分析。结果:共纳入符合标准的文献14篇,与对照组相比,银杏达莫注射液治疗急性脑梗死的总有效率效比数比(OR)合并值3.70,95%可信区间[2.80,4.89],神经功能缺损评分标准化均数差(SMD)合并值-1.02,95%可信区间[-1.16,-0.87]。结论:Meta分析表明银杏达莫注射液具有提高治疗急性脑梗死有效率、改善神经功能缺损的作用,并且无明显不良反应。

Objective：To evaluate the curative effect and safety of Ginkgo leaf extract and diphyridamole injection in the treatment of acute cerebral infarction（ACI）with Meta analysis.Methods：Collected the clinical random-control literature about Ginkgo leaf extract and diphyridamole injection in the treatment of acute cerebral infarction both at home and broad,to evaluate the quality and to extract effective data for meta-analysis using Jadad scoring method.Results：There were 14 researches up to standard.Comparing with the control group,the total effective rate odds ratio[OR]of treatment group was 3.70,95% confidence intervals（CI）was[2.80,4.89],the SMD of neurologic impairment was-1.02,and 95% CI was[-1.16,-0.87].Conclusion：Meta-analysis displayed that Ginkgo leaf extract and diphyridamole injection is effective for ACI and it can increase the effective rate of treating ACI and improve neurologic impairment,which has no significant adverse reactions.