缬沙坦联合氨氯地平对高血压合并糖尿病患者血压及尿微量白蛋白的影响

Effect of Valsartan Combined with Amlodipine on Blood Pressure and Microalbuminuria of Patients with Essential Hypertension and Diabetes Mellitus

目的：观察缬沙坦联合氨氯地平对高血压合并糖尿病患者血压及尿微量白蛋白的影响。方法：选择2014年6月-2015年11月到某院就诊的84例高血压合并糖尿病患者为研究对象,按随机数字表法分为观察组和对照组,每组42例。对照组患者给予缬沙坦治疗,观察组给予缬沙坦加用氨氯地平进行治疗,疗程8周,观察两组患者治疗前后血压及尿微量白蛋白的变化。结果：两组患者经过治疗后,其血压及尿微量白蛋白水平均有明显下降,但观察组相比对照组下降更为明显（P〈0.05）,在治疗效果方面,观察组总有效率达到92.9%,对照组总有效率为76.2%,观察组患者治疗总有效率明显高于对照组（P〈0.05）。结论：缬沙坦联合氨氯地平治疗高血压合并糖尿病效果显著,既能有效控制血压,又能明显降低尿微量白蛋白,保护患者肾功能免受损害。

Objective：To observe the effect of valsartan combined with amlodipine on blood pressure and microalbuminuria of patients with essential hypertension and diabetes mellitus.Methods：Select 84 patients with essential hypertension and diabetes mellitus visited in the hospital from June 2014 to November 2015 and were randomly divided into observation group and control group with 42 cases in each group.The control group was treated with valsartan,and the observation group was given valsartan and amlodipine for 8weeks.Then observe the changes of blood pressure and microalbuminuria in the two groups before and after treatment.Results：After treatment,the blood pressure and microalbuminuria of the patients in two groups were decreased significantly,but the decrease rate of the observation group was lower than that of the control group（P〈0.05）.Meanwhile the total effective rate of the observation group reached 92.9%,and the total effective rate of the control group was 76.2%,and the total effictive rate of the observation group was significantly higher than that of the control group（P〈0.05）.Conclusion：Valsartan combined with amlodipine is significant in the treatment of diabetic hypertension,which can effectively control blood pressure and reduce urinary albumin,protecting renal function from damage.