溶血磷脂酸对细胞迁移的影响及相关分子机制

Effect of Lysophosphatidic Acid on Cell Migration and Its Relative Molecular Mechanisms

溶血磷脂酸(LPA)是一种广泛存在的生物活性磷脂,参与调节细胞的多种生物学行为。研究表明,LPA可以通过特定的G蛋白耦联受体(GPCRs)调控细胞的增殖、分化、迁移和侵袭等生物学行为。已有研究表明,肿瘤的恶化及干细胞介导的组织修复与细胞迁移能力紧密相关。鉴于LPA对肿瘤细胞及干细胞迁移能力的显著影响,本文主要从LPA受体和受体下游主要信号分子两个方面介绍了LPA对肿瘤细胞和干细胞迁移行为的影响及其相关分子机制。

Lysophosphatidic acid （LPA） is a pluripotent lipid mediator and acts via different G-protein-couple LPA receptors. LPA has significant effects on several cellular biological behaviours, such as cell migration, invasion, proliferation and differentiation, etc. Cell migration is essential for tumor progression, and vital for stem cell to repair injured tissues. Increasing evidences have demonstrated that LPA dramatically affects migration capacity of various cells, particularly cancer cells and stem cells. In this paper, we review the effect of LPA on migration of cancer cells and stem cells, and discuss the underlying mechanisms. A better understanding of this process will shed new light on tissue regeneration and the prevention of tumor progression.