PCL-PEG-PCL聚合物的合成及性质

Synthesis and Properties of PCL-PEG-PCL Polymer

PCL-PEG-PCL聚合物具有较好的生物相容性,同时又是很好的可降解材料,用作人体内生物材料时,由于合成过程中所使用具有毒性的催化剂很难完全除掉,亲水性不好,使得其在医学领域的应用受到限制。本研究率先采用无毒NaH为催化剂,具有亲水性、生物相容性的聚乙二醇(PEG)与聚ε-己内酯(PCL)为原料,发生共聚反应,控制单体己内酯与聚乙二醇的加入比例,合成出不同聚合度的高亲水性的PCL-PEG-PCL聚合物,探究了温度、催化剂与单体加入比例对反应的影响。通过GPC、XRD和DSC、TGA对其进行分析检测和表征,揭示其内部结构和规律性。

PCL-PEG-PCL polymer has good biocompatibility, and it is also a good degradable material. Furthermore, there is a good permeability to drugs,so it can be used as sustained-release materials. In the territory of implant materials in vivo, it＇s served as operating suture line, internal fracture fixation material, intravascular stent etc. However, the catalyst used in the synthesis of PCL-PEG-PCL polymer is toxic,and it cannot completely removed,which restricts application of PCL-PEG-PCL polymers in medical field. In this paper,using atoxic Na H as the catalyst, biocompatible monomer PEG and PCL as raw materials, through controlling the monomer ratio of PCL and PEG, hydrophilic PCL-PEG-PCL copolymers with various degree of polymerization were synthesized by copolymerization reaction. Effect of the temperature, ratio of catalyst to monomer on the reaction was investigated. At last, the copolymers were characterized by gel permeation chromatography（GPC）, thermogravimetric analysis（TGA）, X-ray diffractiometer（XRD） and differential scanning calorimeter（DSC）.