乙肝表面抗原阳性与阴性患者消化道溃疡检出率对比分析

Comparison of detection rate of peptic ulcer in patients with positive or negative hepatitis B surface antigen

目的对比分析乙肝表面抗原(HBsAg)阳性与阴性患者消化道溃疡检出率。方法选择2013年5月至2015年5月我院收治的慢性HBV感染患者2 932例,其中2 660例HBsAg阴性患者作为阴性组,272例HBsAg阳性患者作为阳性组,比较两组患者消化道溃疡检出情况以及幽门螺杆菌(HP)检出情况。结果阳性组患者检出消化道溃疡62例(检出率22.79%),其中胃溃疡18例、十二指肠溃疡30例、复合溃疡14例,阴性组患者检出消化道溃疡294例,其中胃溃疡71例、十二指肠溃疡176例、复合溃疡47例,阳性组患者消化道溃疡检出率显著高于阴性组(P<0.05);阳性组患者男性检出消化道溃疡41例(检出率28.28%)、女性检出消化道溃疡21例(检出率16.54%),男性消化道溃疡检出率显著高于女性(P<0.05);阴性组男性检出消化道溃疡156例(检出率11.41%)、女性检出消化道溃疡138例(检出率10.67%),阴性组不同性别检出率差异无统计学意义(P>0.05);阳性组患者HP检出196例(检出率72.06%)、阴性组患者HP检出1 545例(检出率58.08%),两组HP检出率差异具有统计学意义(P<0.05)。结论 HBsAg阳性患者其消化道溃疡、HP感染的检出率显著高于HBsAg阴性者,且消化道溃疡以十二指肠溃疡检出率最高,HBsAg阳性患者男性消化道溃疡检出率明显高于女性,表明乙肝病毒感染与消化道溃疡之间具有着一定的联系。

Objective To compare the detection rate of peptic ulcer in chronic hepatitis B patients with positive or negative hepatitis B surface antigen （HBsAg）. Methods Total 2 932 patients with chronic HBV infection admitted in our hospital from May 2013 to May 2015 were enrolled, including 2 660 cases with negative HBsAg （negative group ） and 272 cases with positive HBsAg （positive group ）. The prevalence of peptic ulcer and Helicobacter pylori （HP） infection were compared between two groups. Results There were 62 cases of peptic ulcers in HBsAg positive group, including 30 cases of gastric ulcer, 18 cases of duodenal ulcer and 14 cases of compound ulcer with a prevalence rate of 22.8%. There were 294 cases of peptic ulcer in HBsAg negative group, including 71 cases of gastric ulcer, 47 cases of duodenal ulcer and 176 cases of combined ulcer with a prevalence rate of 11. 1%. The prevalence of peptic ulcer in HBsAg positive group was significantly higher than that in negative group （ P 〈 0.05 ）. In HBsAg positive group, the prevalence of peptic ulcer in males were higher than that in females（ 16.54% vs 28.28%, P 〈 0.05 ） ; while in HBsAg negative group, there was no significant differences in prevalence rate of peptic ulcer between male and female patients （ 11.41% vs 10.67 %, P 〉0.05 ）. HP positive rate in HBsAg positive group was significantly higher than that in HBsAg negative group （ 72.06% vs 58.08%, P 〈 0.05 ）. Conclusion Chronic hepatitis B patients with positive HBsAg are likely to have peptic ulcer and HP infection, particularly for male patients.