摘要
胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)是最常见的胰腺癌病理类型,亦是预后最差的恶性肿瘤。近年来胰腺肿瘤干细胞(pancreatic cancer stem cell,PCSC)的研究取得了诸多进展,PCSC与胰腺肿瘤的侵袭、转移及复发都有着直接联系。本研究将从PCSC的相关标志物、肿瘤微环境及靶向治疗等角度对近年来PCSC的相关研究进展作一综述。
Pancreatic ductal adenocarcinoma（PDAC） is the most common histopathological type of pancreatic cancer with a poor prognosis. Pancreatic cancer stem cell （PCSC） are considered a direct connection with the invasion, metastasis and recurrence of PDAC. This article reviews the recent research progress on the bio-markers, tumor microenvironment of PCSC and it＇s potential application in targeted therapy.
出处
《同济大学学报（医学版）》
CAS
2016年第4期119-123,共5页
Journal of Tongji University(Medical Science)
基金
上海浦东新区卫生系统领先人才(PWR12012-01)
关键词
胰腺肿瘤
肿瘤干细胞
标志物
肿瘤微环境
pancreatic cancer
cancer stem cells
bio-markers
tumor microenvironment
