摘要
微小RNA(miRNA)是近年来研究较多的内源性非编码小RNA,能与靶基因3'UTR进行不完全配对,通过序列特异性翻译抑制或信使RNA降解来调控靶基因表达,参与细胞发育、增殖、分化、凋亡等一系列重要生物学进程,并在肿瘤的发生和发展过程中起着重要作用。越来越多的研究证实miRNA与肝细胞癌的发生发展、侵袭转移、血管生成、术后复发等生物学行为相关;并有研究者将miRNA用于肝细胞癌的早期诊断及治疗。本文就与肝细胞癌相关的miRNA研究作一综述。
MicroRNAs （miRNAs） are endogenous non coding small RNA, which can pair incompletely with 3＇UTR of target genes. MicroRNA regulate the expression of target genes through sequence specific translation inhibition or messenger RNA degradation, involving in cell growth, proliferation, differentiation and apoptosis and also playing an important role in on cogenesis. Studies have shown that miRNAs are related to occurrence, development, invasion and metastasis, angiogenesis, postoperative recurrence of hepatoceUular carcinoma, indicating that they maybe used for early diagnosis and treatment of hepatocellular carcinoma. In this paper, we reviewed the research progress of to hepatocellular carcinoma-related miRNAs.
出处
《同济大学学报（医学版）》
CAS
2016年第4期124-127,132,共5页
Journal of Tongji University(Medical Science)
基金
上海市卫生和计划生育委员会青年科研项目(2013Y121
20144Y0047)
国家自然基金面上项目(81272662)
关键词
肝细胞肿瘤
微小RNA
研究进展
hepatocellular carcinoma
microRNA
research progress
