长脉宽1064nm激光联合盐酸阿莫罗芬治疗甲真菌病疗效观察

Clinical Efficacy of Long-pulsed 1064nm Laser Combined with Amorolfine Hydrochloride in the Treatment of Patients with Onychomycosis

目的:观察长脉宽1 064 nm激光联合5%盐酸阿莫罗芬搽剂治疗甲真菌病的临床疗效。方法:甲真菌病患者106例随机分为观察组与对照组各53例。对照组采用5%盐酸阿莫罗芬搽剂治疗,观察组在对照组基础上结合长脉宽1 064 nm激光治疗。两组疗程均为6个月。比较两组患者治疗疗效、病区甲板长度和健区甲板长度、真菌清除情况及药品不良反应。结果:观察组总有效率为90.57%,真菌清除率为86.79%,两项指标均高于对照组(75.47%和67.92%,P<0.05)。治疗后,两组患者病区甲板长度明显减少,健区甲板长度明显增加(P<0.05);且观察组患者病区甲板长度和健区甲板长度均优于对照组患者(P<0.05)。两组均未见药品不良反应发生。结论:长脉宽1 064 nm激光联合5%盐酸阿莫罗芬搽剂治疗甲真菌病临床效果显著,安全可靠,具有重要研究价值。

Objective： To investigate the clinical efficacy of long-pulsed 1064nm laser combined with amorolfine hydrochloride in the treatment of patients with onychomycosis. Methods： Totally 106 cases of patients with onychomycosis were randomly divided into the observation group （n = 53 ） and the control group（ n = 53 ） according to the random number table. The control group was given 5% amorolfine hydrochloride liniment, while the observation group was treated with long-pulsed 1064nm laser additionally. The course of treatment was 6 months. The clinical efficacy, length of deck in ward areas, length of deck in health zone, clearance of mycology and adverse reactions were compared between the groups. Results： The total effective rate of the observation group（90.57% ） was signifi- cantly higher than that of the control group（75.47%, P 〈 0. 05 ）. After the treatment, the length of deck in ward areas in both groups were significantly decreased, while the length of deck in health zone were significantly increased （ P 〈 0. 05 ）. The length of deck in ward areas in the observation group was significantly lower than that in the control group, while the length of deck in health zone was significantly higher than that in the control group（ P 〈 0. 05 ）. The clearance rate of mycology in the observation group （86.79%） was significantly higher than that in the control group （67.92%, P 〈 0. 05 ）. There were no serious adverse reactions during the treatment course. Conclusion： Long-pulsed 1064nm laser combined with 5% amorolfine hydrochloride liniment in the treatment of patients with onychomycosis has remarkable, sate and reliable clinical effects, which shows important study value.