酮康唑、硝酸咪康唑β-环糊精包合物的工艺优选

Preparation Technology Optimization of Ketoconazole and Miconazole Nitrate β- Cyclodextrin Inclusion Compound

目的:优选β-环糊精包合酮康唑、硝酸咪康唑的工艺。方法:通过正交试验设计,以β-环糊精与酮康唑的质量比例,包合温度,包合时间为考察因素,筛选出最佳包合工艺。结果:β-环糊精包合酮康唑、硝酸咪康唑的最佳工艺为:β-环糊精与酮康唑质量比为8∶1,包合温度50℃,超声包合时间50 min。结论:优选的包合工艺简单易行。

Objective： To optimize the preparation technology of ketoconazole and miconazole nitrate β-cyclodextrin inclusion com- pound. Methods： The weight ratio of β-cyclodextrin to ketoconazole, inclusion temperature and inclusion time as the testing factors, the optimal inclusion technology was screened by orthogonal experiments. Results： The optimum inclusion conditions were as follows： the weight ratio of β-cyelodextrin to ketoconazole was 8 ： 1, the inclusion temperature was 50℃, and the ultrasonic time was 50 min. Conclusion： The optimized β-cyclodextrin inclusion process is simple and convenient to carry out.