布拉氏酵母菌联合乳果糖对儿童功能性便秘患者血清肠神经递质指标的影响及疗效

Influence and curative effect of saccharomyces boulardii combined with lactulose on serum enteric neurotransmitter indexes of children with functional constipation(FC)

[目的]探讨布拉氏酵母菌联合乳果糖对儿童功能性便秘（FC）患者血清肠神经递质指标的影响及疗效。[方法]选取儿科门诊治疗的儿童FC患者86例,随机分为观察组和对照组各43例。2组患儿均予以多饮水、调整饮食和进行排便锻炼等基础治疗。对照组患儿予以乳果糖口服液5ml//次,2次/d,口服。观察组患儿在对照组基础上加用布拉氏酵母菌散剂0.25g/次,1次/d,温开水冲服,2组患儿疗程均为6周。观察2组患儿治疗前后血清肠神经递质一氧化氮（NO）和生长抑素（SS）指标的变化,并比较其临床效果及药物不良反应。[结果]对照组及观察组患儿分别失访4例与6例,2组患儿失访率比较差异无统计学意义（P〉0.05）。治疗6周后,2组患儿血清NO和SS指标较前明显下降,且治疗后观察组血清NO和SS指标明显低于对照组（P〈0.05）;在临床总有效率方面,观察组患儿明显高于对照组（χ~2=4.79,P〈0.05）。[结论]布拉氏酵母菌散联合乳果糖治疗儿童FC的疗效及安全性均较佳,作用可能与其能降低血清NO和SS指标,促进胃肠蠕动,缓解便秘症状密切相关。

[Objective]To investigate the influence and curative effect of Saccharomyces Boulardii combined with Lactulose on serum enteric neurotransmitter indexes of children with functional constipation（FC）.[Methods]86cases of children with FC,who were given medical treatment in pediatric outpatient department,were selected,and divided into observation group and control group at random,with 43 cases of children in either group.The children in two groups were given plenty of water,diet adjustment,defecation exercise and other basic medical treatment.The children in control group were given 5ml Lactulose oral solution per time,twice a day,through the mouth,while the children in observation group were additionally given 0.25 g Saccharomyces Boulardii powder per time,once a day,with warm boiled water,for 6weeks＇ course of treatment.The changes of serum nitric oxide（NO）and somatostatin（SS）of serum enteric neurotransmitter indexes of children in two groups before and after medical treatment were observed,and the clinical curative effect and drug adverse reaction（DAR）were compared as well.[Results]4and 6cases of loss to follow up appeared on children in control group and observation group respectively,and after comparing the loss rates to follow up of children in two groups,no statistical differences appeared（P0.05）.After 6weeks＇ medical treatment,NO and SS indexes of children in two groups obviously declined thanbefore,and serum NO and SS indexes of children in observation group were much lower than those in control group（P0.05）.Total clinical efficiency of children in observation group was much higher than that in control group（χ~2=4.79,P0.05）.[Conclusion]Saccharomyces Boulardii combined with Lactulose had favorable curative effect on children with FC with high security,whose mechanism may have close effect on reducing serum NO and SS indexes,improving gastrointestinal motility and relieving constipation symptom.