摘要
Pyroptosis,a lytic,highly inflammatory form of programmed cell death,plays an important role in the defense against microbial infections and danger signals.However,excessive pyroptosis can be detrimental to host defense.
Pyroptosis, a lytic, highly inflammatory form of pro- grammed cell death, plays an important role in the defense against microbial infections and danger signals. However, excessive pyroptosis can be detrimental to host defense. Pyroptosis is uniquely dependent on inflammatory caspases such as caspase-1, murine caspase-ll, and its human hom- ologs caspases-4 and -5. Caspase-1 is a central component of canonical NLRP3, NLRC4, AIM2,