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Formation of membrane pores by gasdermin-N causes pyroptosis 被引量：1

Formation of membrane pores by gasdermin-N causes pyroptosis
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摘要 Pyroptosis,a lytic,highly inflammatory form of programmed cell death,plays an important role in the defense against microbial infections and danger signals.However,excessive pyroptosis can be detrimental to host defense. Pyroptosis, a lytic, highly inflammatory form of pro- grammed cell death, plays an important role in the defense against microbial infections and danger signals. However, excessive pyroptosis can be detrimental to host defense. Pyroptosis is uniquely dependent on inflammatory caspases such as caspase-1, murine caspase-ll, and its human hom- ologs caspases-4 and -5. Caspase-1 is a central component of canonical NLRP3, NLRC4, AIM2,
作者 Xiaopeng Qi
机构地区 Key Laboratory of Animal Models and Human Disease Mechanisms
出处 《Science China(Life Sciences)》 SCIE CAS CSCD 2016年第10期1071-1073,共3页 中国科学（生命科学英文版）
关键词 细胞程序性死亡 CASPASE 膜孔 宿主防御 微生物感染 半胱天冬酶 组成部分 炎症
分类号 R363 [医药卫生—病理学]
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参考文献9

  • 1Aglietti, R.A., Estevez, A., Gupta, A., Ramirez, M.G., Liu, P.S., Kayagaki, N., Ciferri, C., Dixit, V.M., and Dueber, E.C. (2016). GsdmD p30 elicited by caspase-ll during pyroptosis forms pores in membranes. Proc Natl Acad Sci, USA 113, 7858-7863.
  • 2Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.-C., and Shao, F. (2016). Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 535, 111-116.
  • 3Hagar, J.A., Powell, D.A., Aachoui, Y., Ernst, R.K., and Miao, E.A. (2013). Cytoplasmic LPS Activates Caspase-ll: Implications in TLR4-Independent Endotoxic Shock. Science 341, 1250-1253.
  • 4Kayagaki, N., Stowe, I.B., Lee, B.L., O'Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q.T.,Liu, P., Lill, J.R., Li, H., Wu, J., Kummerfeld, S., Zhang, J., Lee, W.P., Snipas, S.J., Salvesen, G.S., Morris, L.X., Fitzgerald, L,, Zhang, Y., Bertram, E.M., Goodnow, C.C., and Dixit, V.M. (2015). Caspase-ll cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526, 666-671.
  • 5Kayagaki, N., Wong, M.T., Stowe, I.B., Ramani, S.R., Gonzalez, L.C., Akashi-Takamura, S., Miyake, K., Zhang, J., Lee, W.P., Muszyriski, A., Forsberg, L.S., Carlson, R.W, and Dixit, V.M. (2013). Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science 341, 1246-1249.
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Science China(Life Sciences)
2016年 第10期

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