补锌辅助治疗小儿轮状病毒肠炎的疗效及其对腹泻的预防作用

The effect of zinc supplementation in the treatment of rotavirus enteritis and its preventive on diarrhea

目的研究补锌对治疗小儿轮状病毒肠炎的疗效及其对腹泻的预防作用。方法选择2015年3月至2015年12月间在本院确诊为小儿轮状病毒性肠炎的患儿共160例,随机分为对照组和观察组各80例。对照组采用常规治疗,观察组在此基础上加用补锌制剂辅助治疗。观察两组的临床疗效,临床症状持续时间及治疗后心肌酶水平。对两组患儿进行3个月的随访,并记录比较两组腹泻复发率情况。结果观察组总有效率为90.00%,对照组为76.25%,两组间有效率差异有统计学意义(P<0.05)。观察组患儿的发热、呕吐、腹泻持续时间和脱水纠正时间明显短于对照组,经治疗观察组患儿心肌酶水平明显低于对照组,且观察组1、2、3月腹泻复发率和三个月内重型腹泻复发率明显低于对照组,比较差异有统计学意义(P<0.05)。结论对轮状病毒肠炎患儿加以补锌辅助治疗可有效提高临床疗效、缓解病情、维持患儿心肌酶水平平稳,并可以有效预防患儿三个月内的腹泻复发,值得进一步研究推广。

objective To study The effect of zinc supplementation in the treatment of rotavirus enteritis and its preventive on diarrhea. Method 160 cases of children with rotavirus enteritis from March 2015 to December 2015, according to the random number table were randomly divided into control group and observation group. The control group were treated with routine treatment, and the observation group were treated with zinc supplementation on the basis of the observation group. To observe two groups Clinical efficacy, duration of clinical symptoms and the level of myocardial enzymes. Patients of the two groups were followed up for 3 months, and the recurrence rate of diarrhea was recorded and compared between the two groups. Results The total effective rate of observation group was 90%, and the control group was 76.25%, the difference was statistically significant （P〈0.05）.The children of observation group with fever, vomiting, diarrhea continued time and correct dehydration time significantly shorter than the control group, the myocardial enzyme level and 1, 2, 3 month recurrence of diarrhea rate as well as three months the recurrence of severe diarrhea rate of the observation group was significantly lower than that of the control group, the difference is also statistically significant （P 〈 0.05）. Conclusion The children with rotavirus enteritis to zinc supplementation therapy can effectively improve the clinical efficacy, remission and recovery of myocardial enzyme level in children, and can effectively prevent the recurrence of diarrhea in children three months, worth further study and promotion.