饮酒、吸烟与冠状动脉病变程度的相关性研究

Research on Correlation of between Drinking and Smoking in Coronary Artery Disease

目的:探讨饮酒、吸烟与冠状动脉病变程度的相关性。方法:抽取行冠脉造影的男性患者(343例),排除患有高血压病、糖尿病、肝肾功能等异常的患者,根据患者是否吸烟、饮酒将其分为四组,吸烟+饮酒组(86例),吸烟+非饮酒组(135例),饮酒+非吸烟饮酒组(16例),非吸烟+非饮酒组(106例)。通过Gensini积分系统评价和比较各组冠脉病变的情况,分析评估冠心病的风险因素以及饮酒、吸烟与冠心病的关系。结果:吸烟+非饮酒组Gensini评分最高(33.89±31.14)分别与另外三组有统计学意义(P<0.05)。饮酒+非吸烟组最低(9.31±10.88),分别与另外三组有统计学意义(P<0.05)。单因素分析结果显示年龄、饮酒、TG、HDL-C是发生冠心病的危险因素,logistic回归分析结果显示饮酒是发生冠心病的保护因素,年龄与TG是发生冠心病的危险因素。结论:吸烟为冠状动脉病变高危因素,饮酒是发生冠心病的保护因素。

Objective： To investigate the correlation between drinking, smoking and coronary lesion severity. Methods： 343 cases of male patients examined by coronary angiography were selected, those who had high blood pressure, diabetes, liver, renal dysfunction were excluded. The patients were divided into four groups, smoking and drinking group （86 cases）, smoking ＋ no drinking group （135 cases）, no smoking＋drinking group （16 cases）, no smoking and no drinking group （106 cases）. The situation of coronary artery was evaluated by Gensini coronary score, logistic regression analysis was performed to assess the risk factors of coronary artery lesion. Results： Gensini score is highest （33.89±31.14） in smoking ＋ no drinking group compared with that in other three groups （P〈0.05）. Gensini score is 9.31 ± 10.88 in No smoking＋drinking group, which was lower than other groups （P 〈 0.05）. Univariate analysis showed that age, alcohol consumption, TG, HDL-C are risk factors for coronary heart disease, logistic regression analysis showed that alcohol consumption was protective factors of coronary heart disease, age and TG were risk factors of coronary heart disease. Conclusion： Smoking was a risk factor of coronary artery diseases, while drinking was a protective factor of coronary heart disease.