CXCL12/CXCR4轴与心肌梗死关系的研究进展
摘要
趋化因子CXCL12是趋化因子受体CXCR4的特异性配体。CXCL12/CXCR4轴能通过介导干或祖细胞向梗死部位归巢、提高间充质细胞存活率、促进血管再生、减少心肌细胞凋亡对心肌梗死心脏发挥保护作用,但也存在引起内皮过度增生导致血管腔狭窄和心肌梗死后再狭窄的可能。CXCL12/CXCR4轴在心肌梗死过程中的确切作用尚不明确。
出处
《山东医药》
CAS
北大核心
2016年第33期102-104,共3页
Shandong Medical Journal
基金
浙江省新苗人才计划项目(2015R413052)
参考文献19
-
1Agarwal U,Ghalayini W,Dong F,et al.Role of cardiac myocyte CXCR4 expression in development and left ventricular remodeling after acute myocardial infarction[J].Circ Res,2010,107(5):667-676.
-
2Thackeray JT,Derlin T,Haghikia A,et al.Molecular imaging of the chemokine receptor CXCR4 after acute myocardial infarction[J].JACC Cardiovasc Imaging,2015,8(12):1417-1426.
-
3Shih CM,Chen YH,Lin YW,et al.MK-0626,a dipeptidyl peptidase-4 inhibitor,improves neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric oxide synthetase expression[J].Curr Med Chem,2014,21(17):2012-2022.
-
4Huber BC,Stefan B,Alexander S,et al.Parathyroid hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4(+)stem cells into the ischaemic heart[J].Cardiovasc Res,2011,90(3):529-537.
-
5Herberg S,Shi X,Johnson MH,et al.Stromal cell-derived factor-1βmediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells[J].Plo S One,2013,8(3):e58207.
-
6Huang W,Wang T,Zhang D,et al.Mesenchymal stem cells overexpressing CXCR4 attenuate remodeling of postmyocardial infarction by releasing matrix metalloproteinase-9[J].Stem Cells Dev,2011,21(5):778-789.
-
7Tang JM,Wang JN,Zhang L,et al.VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart[J].Cardiovasc Res,2011,91(3):402-411.
-
8Youn SW,Lee SW,Lee J,et al.COMP-Ang1 stimulates HIF-1α-mediated SDF-1 overexpression and recovers ischemic injury through BM-derived progenitor cell recruitment[J].Blood,2011,117(16):4376-4386.
-
9Hamesch K,Subramanian P,Li X,et al.The CXCR4 antagonist POL5551 is equally effective as sirolimus in reducing neointima formation without impairing re-endothelialisation[J].Thromb Haemost,2012,107(2):356-368.
-
10Rong XS,Li MQ,Xu Y,et al.Injection of Cardiac Stem Cells Prolongs the Survival of Cardiac Allograft Rats[J].Am J Med Sci,2015,349(1):67-71.
-
1吴东辉,秦爱军,朱晏伟.CXCL12/CXCR4信号转导通路在大肠癌转移分子机制中的研究进展[J].辽宁中医药大学学报,2010,12(9):200-202. 被引量：4
-
2丁灿,卿国忠.罗格列酮对急性肺损伤的保护作用[J].国际病理科学与临床杂志,2013,33(6):539-543.
-
3王明华,黄铁柱.CXCL12/CXCR4在甲状腺疾病中的研究进展[J].郧阳医学院学报,2009,28(2):195-197. 被引量：1
-
4吴欧,潘海峰,叶冬青.Toll样受体9与红斑狼疮易感性关系的研究进展[J].国际遗传学杂志,2009,32(2):130-135.
-
5戴辰程,戴冽（审校）.缺氧诱导因子-1与类风湿关节炎[J].国外医学（免疫学分册）,2005,28(5):298-302. 被引量：3
-
6胡卫东,郑新民,熊斌,汪必成,张卫兵.趋化因子及其受体CXCL12／CXCR4在人前列腺癌转移机制中的作用[J].中华微生物学和免疫学杂志,2008,28(10):879-884. 被引量：7
-
7冯亚红,张姣,于小勇.血液透析联合血液灌流在难治性高血压治疗中应用观察[J].陕西医学杂志,2012,41(7):911-912. 被引量：4
-
8赵彩彦,王亚东.胰岛素增敏剂在非酒精性脂肪性肝炎诊治中的应用[J].临床消化病杂志,2007,19(4):209-212.
-
9曹伟良,肖建华.脂肪因子Apelin对2型糖尿病的调控作用[J].微生物学免疫学进展,2016,44(6):93-95. 被引量：3
-
10姜政,周伟,李新钢,于金明,江玉泉.人脑胶质瘤CXCL12基因的甲基化分析研究[J].中华神经外科杂志,2009,25(6):508-512.
