卵巢非特异性类固醇细胞肿瘤1例报告及文献复习

Ovarian nonspecific steroid cell tumor:A case report and literature review

目的:探讨1例卵巢非特异性类固醇细胞肿瘤的临床特点、诊治经验和诊治过程。方法:回顾性分析1例卵巢非特异性类固醇细胞肿瘤患者的临床资料,并进行相关文献复习。结果:该例患者表现为闭经和男性化等特征;妇科超声提示,右卵巢内见53mm×39mm实性光团回声,见点状血流,考虑为右侧卵巢恶性肿瘤,行剖腹探查术。术后病理见圆形、多角形肿瘤细胞呈巢状(器官样)排列,胞浆空亮或嗜酸性颗粒样,间质稀少,核呈圆形或卵圆形,可见核仁。核分裂相少见,未见出血、坏死灶;免疫组织化学染色,inhibin、calretinin和vimentin阳性。确诊为卵巢非特异性类固醇细胞肿瘤。术后随访3个月,无复发。结论:卵巢非特异性类固醇细胞肿瘤确诊需结合临床表现及术后病理,手术是其主要治疗方法。

Objective：To study the clinical features, experiences of diagnosis and treatment, and treatment process of ovarian nonspecific steroid cell tumor. Methods：The clinical materials of one case of ovarian nonspecific steroid cell tumor were retrospectively analyzed,and the related literaturels were reviewed. Results：The patient displayed amenorrhea and masculine characteristics.Preoperative ultrasonography demonstrated the solid tumor of 53 mm ×39 mm on the right ovary,consideration for the right side of ovarian malignant tumor,and laparotomy was performed.The pathologic results showed that the tumor cells were arranged in nests,and the cytoplasm was bright or eosinophilic, and the nucleus were round or oval with nucleolus.The immunohistochemical staining results revealed that calretinin,vimentin and inhibin were positive in the tumor cells.The patient was diagnosed with ovarian nonspecific steroid cell tumor.The postoperative follow-up of 3 months was performed,and there was no recurrence.Conclusion：The diagnosis of ovarian nonspecific steroid cell tumor should be combined with the clinical manifestation and pathologic results,and operion is the main treatment method.