血清25(OH)D_3水平在哮喘发作期、治疗后的变化及与肺功能的相关性分析

Relationship between serum 25(OH)D_3 and lung function of patients with bronchial asthma at acute episode

目的探讨哮喘患者急性期及治疗后血清25(OH)D_3水平与肺功能及病情的相关性。方法选取来我院诊治的急性发作期哮喘患者60例为研究组,分为成年亚组及未成年亚组各30例,于治疗前及治疗后7d(缓解期),治疗后3个月测定其血清25(OH)D_3水平、第1秒用力呼气容积占预计值百分比(FEV1%pred)、呼气峰流速(PEF),于治疗前及治疗3个月后进行哮喘控制评分(ACT);于上述时间点选择健康人群为对照组测量相应指标,比较健康与患病人群两亚组间各项指标差异,并分析治疗前及3个月后研究组两亚组血清25-(OH)D_3水平与其他指标间的相关性。结果治疗前发作期、开始治疗后7d及3个月,对照组与研究组各亚组之间,各指标均有显著差异;而研究组治疗7d后血清25(OH)D_3水平也远高于治疗前。治疗前两亚组血清25(OH)D_3与FEV1%pred、PEF间无明显相关性;而开始治疗3个月后,两亚组血清25(OH)D_3与FEV1%pred、PEF及ACT评分均有显著正相关(未成年r=0.81,0.79,0.82;P均<0.05;成年组r=0.61,0.54,0.70;P均<0.05)。结论哮喘患者发作、缓解及稳定期血清25(OH)D_3水平在病情的诊断与预后评估中能发挥重要作用,值得进一步大样本深入研究。

Objective To study relationship between serum 25（OH）D3 and lung function of patients with bronchial asthma at acute episode. Methods 60 asthma patients were chosen as the research group, with 30 minor cases and 30 adult cases. 60 healthy people were chosen as the control group. PF, ACT and 25（OH）D3 were meas-ured before and after the treatment. The Results were analyzed. Results There were significant differences be-tween the indexes of subgroups before and 7days and 3 months after the treatment. The level of 25（OH）D3 in the re-search group before treatment was lower than 7d after treatment. There was no significant correlation between serum 25（OH）D3 concentration with FEV1%pred and PEF in the 2 subgroups before treatment, but they were positively correlated 3 months after treatment （Minor r=0. 81, 0. 79, 0. 82; adult r=0. 61, 0. 54, 0. 70, P〈0. 05）. Con-clusion Serum 25（OH）D3 can get a positive effect on the diagnosis condition assessment and treatment of asthma.