丙酸氟替卡松预防婴幼儿毛细支气管炎后喘息的临床观察

Clinical observation of glucocorticoid inhalation in preventing wheeze attack after virus infection

目的观察丙酸氟替卡松气雾剂吸入预防婴幼儿病毒诱发性喘息发作的临床效果。方法将145例符合毛细支气管炎诊断的婴幼儿随机分为预防组75例、对照组70例,两组在常规治疗出院后,预防组采用丙酸氟替卡松吸入3个月,而对照组不做相应处理。出院后随访1年,比较1年内两组婴幼儿喘息的发病构成比、喘息发作次数及发作持续时间。结果在随访一年内,预防组中有21例患儿未发生喘息,37例发生1次喘息,17例发生2次以上喘息;对照组有5例患儿未发生喘息,19例发生1次喘息,46例发生2次以上喘息。预防组发生喘息患儿平均喘息持续时间也较对照组明显缩短。结论吸入糖皮质激素早期干预可以缓解毛细支气管炎患儿后期病毒诱发性喘息反复发作。

Objective To observe glucocorticoid inhalation to prevent wheeze attack after virus-induced in-fant bronchiolitis with allergic history. Methods 145 infants with bronchiolitis were divided into two groups： the control group and the observation group. The two groups received budesonide and terbutaline inhaling combined with relieving cough therapy after admission to hospital, and the observation group was given fluticasone propionate inhala-tion for 3 months after discharge. After 1 year follow-up, the prevalence of wheeze of the two groups were compared. Results Within 1-year follow-up, there were 21 cases without wheeze attack, 37 cases occurred one time, 17 cases with 2 or more times in the prevention group. Meanwhile, there were 5 of 70 cases without wheeze attack, 19 cases occurred one time, 46 cases occurred 2 or more times in the control group. The average lasting time of wheeze in the prevention group was significantly shorter than that of the control group. Conclusion The early intervention of in-haled corticosteroids can prevent effectively virus-induced wheezing attacks after infant bronchiolitis.