冰冻血小板与新鲜血小板临床输注效果比较分析

Comparison of Clinical Infusion Effect Between Frozen Platelet and Fresh Platelet

目的：比较新鲜血小板与冰冻血小板在临床输注中的效果，探讨两类血小板的最佳用途。方法抽取2013年1月—2015年6月输注血小板的患者274例（其中输注新鲜血小板患者156例，输注冰冻血小板患者118例），比较两组患者输注血小板后的外周血小板计数变化、回收率（PPR）、止血情况等。结果输注了1个治疗量的血小板后，新鲜组外周血小板计数升高（30.56±4.20）×109/L，血小板回收率有效者占61.5%。冰冻组外周血小板计数升高（12.23±±3.76）×109/L，血小板回收率有效者占21.2%。新鲜组外周血小板计数提升、回收率均优于冰冻组，二者差异均有统计学意义（P＜0.05）；两组血小板输注后止血效果相当，二者差异无统计学意义（P＞0.05）。结论在提升血小板计数水平上，新鲜血小板优于冰冻血小板。但两者均能有效控制和预防出血，均可获得较好的治疗效果，在新鲜血小板不充足的情况下冰冻血小板可作为其重要的补充。

ObjectiveTo analyze the differences of clinical infusion effect between frozen and fresh platelets and to explore the best use of two types of platelets.Methods 274 patients who received platelet infusion during January 2013 to June 2015 （156 patients received fresh platelet infusion, 118 patients received frozen platelet infusion）. The change of peripheral blood platelet count, percentage platelet recovery （PPR）, the bleeding situation after the platelet transfusion completion were compared between the two groups.Results After a treatment amount of platelet infusion the peripheral blood platelet count increased （30.56±4.20）×109/L and the percentage platelet recovery effectively account for 61.5% in fresh platelet group. By comparison, the peripheral blood platelet count increased （12.23±3.76）×109/L and the percentage platelet recovery effectively account for 21.2% in frozen platelet group. This group of infusion of fresh platelets is superior to the infusion of frozen platelets, in the ascension of peripheral blood platelet count and in terms of percentage platelet recovery, the differences were statistically signiifcant （P〈0.05） between the two groups. There was no statistically signiifcant difference on hemostatic effect between the two groups after platelets infusion （P〉0.05）. ConclusionThe capacity of improving platelet count in fresh platelet group is superior to that in frozen platelet group. They are helpful to prevent bleeding and to achieve good therapeutic effect by using two type of platelet infusion. Under the conditionof the inadequate fresh platelet frozen platelets could be used as an important supplement.