降钙素原在鉴别不同病原体感染儿童肺炎中的应用

Application of procalcitonin in the identification of pneumonia with different pathogens infection in children

目的探讨血清降钙素原(procalcitonin,PCT)在鉴别儿童细菌性肺炎、支原体肺炎与病毒性肺炎感染中的作用。方法利用电化学发光免疫测定法对143例社区获得性肺炎的住院患儿(其中支原体肺炎组53例、病毒性肺炎组65例、细菌性肺炎组25例)进行PCT检测,并同时对C-反应蛋白(CRP)和白细胞(WBC)进行联合分析。结果细菌性肺炎组的PCT值(0.102μg/L)明显高于支原体肺炎组(0.076μg/L)和病毒性肺炎组(0.065μg/L),差异均有统计学意义(P<0.05);而支原体肺炎组和病毒性肺炎组的PCT值差异无统计学意义(P>0.05)。结论 CAP患儿血清PCT检测对早期诊断细菌性肺炎有重要意义,是一种优于WBC与CRP的敏感指标。

Objective To investigate the clinical use of procalcitonin（ PCT） in the diagnosis of bacterial pneumonia,mycoplasma pneumonia and viral pneumonia. Methods The serum PCT levels,as well as CRP levels,WBC counts,were measured in143 hospitalized patients with community acquired pneumonia（ CAP） including 53 cases with mycoplasma pneumonia,65 cases with viral pneumonia,and 25 cases with bacterial pneumonia by electrochemiluminescence immunoassay（ ECLIA）.Results The PCT value of mycoplasma pneumonia（ 0. 102 μg / L） was significantly higher than the viral pneumonia group（ 0. 076 μg/L） and the bacterial pneumonia group（ 0. 065 μg/L）,with the differences statistically significant（ P 0. 05）.While,the PCT value difference between mycoplasma pneumonia group and viral pneumonia group was not statistically significant（ P 0. 05）. Conclusion Serum PCT levels in children with CAP plays an important role in identifying bacterial pneumonia,which is a sensitive index than WBC counts and CRP level.