新疆维吾尔族和汉族天疱疮患者临床特征研究

Analysis of pemphigus between the Uyghur and Han nationalities in Xinjiang:A hospital-based study

目的:比较新疆地区维吾尔族和汉族天疱疮患者临床特征。方法:回顾性分析121例维吾尔族、汉族天疱疮初次住院患者的临床资料(维吾尔族59例,汉族62例),总结其临床特点,从发病年龄、临床分型、黏膜受累情况及病情分级等几个方面分析新疆地区维吾尔族和汉族天疱疮的差异。结果:维吾尔族患者和汉族患者相比,其发病年轻化、黏膜受累、患寻常型天疱疮几率及病情严重程度均显著增加,差异有统计学意义(P<0.05)。结论:维吾尔族天疱疮患者与汉族人群相比更倾向青中年发病,更易患寻常型天疱疮,且更易发生黏膜损害,死亡率明显高于汉族。

Objective：To compare the difference in clinical phenotype of the patients with pemphigus between the Uyghur nationality and Han nationalities in Xinjiang province.Methods：The clinical data of 121 patients with pemphigus,firstly admitted to our hospital,were analyzed.From several aspects（e.g.,onset age,clinical classification,mucosal involvement and disease classification）,we studied the clinical differences for the pemphigus between the Uyghur and Han nationalities.Results：Compared with patients of Han nationality,those of Uyghur nationality showed increased frequency of mucosal involvement,the risk of suffering from ordinary pemphigus and the severity of the illness（all P〈0.05）.Conclusion：Compared with Han nationality,pemphigus of the Uyghur nationality appears more in young and middle-aged patients.These patients are more likely to suffer from ordinary pemphigus and occur mucosal damage：in addition,mortality rates are significantly higher.