摘要
pH敏感聚合物胶束以其粒径小、载药量高、可控释药等优势近年来受到广泛关注,特别对于抗肿瘤药物的靶向递送来说,p H敏感聚合物胶束呈现出极大的应用潜力。本文主要从p H敏感聚合物胶束作为药物载体的理论基础、类型和p H敏感机制等方面综述了p H敏感聚合物胶束纳米给药系统的研究进展。
pH-sensitive polymeric micelles have received increasingly intensive attention due to their considerable advantages such as small particle size,high drug loading,and controlled release. They have exhibited huge potential of application in the targeted delivery of anticancer drugs. This review highlights recent progress of p H-sensitive polymeric micelles as drug carriers in respects of the theoretical basis,types,and p H-sensitivity mechanisms.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2016年第19期2218-2224,共7页
Chinese Journal of New Drugs
关键词
pH敏感聚合物胶束
给药系统
pH敏感性机制
纳米递药系统
超分子聚合物
大分子自组装
pH-sensitive polymeric micelles
drug delivery system
pH-sensitivity mechanism
nano-drug delivery system
supramolecular polymers
macromolecular self-assembly
