创面愈合依然是“盲人摸象”

Wound healing is still a game of ＂blind men and an elephant＂

创面过度愈合（如烧伤创面愈合后形成增生性瘢痕）和难愈性创面（如糖尿病溃疡创面），作为医学领域亟待攻克的难题，虽然经过长期的研究关注，例如21世纪初，德国研究瘢痕形成机制的1位学者与笔者均收集了一些瘢痕疙瘩家系标本，但国内外至今尚未取得突破性的研究成果，其原因为何？

The wound healing includes non-healing and overhealing of the wounds. The results of wound healing are well known by people such as non-healing of the diabetic ulcer or hypertrophic scar after deep burn. In this issue, three papers involve in wound healing, one about autologous adipose-derived mesenchymal stem cells injected into wound or scar of rabbit ear, one about severe hypoxia and hypoalbuminemia inducing human hypertrophic scar derived fibroblast apoptosis in vitro, and another about the dysfunction of protein kinase B/mammali- an target of rapamycin signaling pathway contributing to the pathophysiological characteristics of diabetic skin and non-heal- ing wound. The basic problem of hypertrophic scar study is lac- king an ideal animal model. Although rabbit ear model or red Duroc pig model has been used widely for study on hypertrophic scar, they can not fully represent human dermal fibrosis after deep trauma on the skin. I recommend A novel nude mouse model of hypertrophic scarring using scratched full thickness human skin grafts recently published in Advances in Wound Care to the readers. The author emphasizes that the wound heal- ing study is still in the situation like the game of ＂blind men and an elephant＂.