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结外鼻型自然杀伤／T细胞淋巴瘤发病机制的研究进展

Research progress on pathogenesis of extranodal natural killer/T-cell lymphoma, nasal type
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摘要 结外鼻型自然杀伤／T细胞淋巴瘤（ENKTCL）是一种有高度侵袭性的非霍奇金淋巴瘤（NHL），具有特殊的流行病学特征，目前其发病机制尚未明确，治疗上仍面临诸多挑战。近年，有较多研究报道指出，EB病毒（EBV）感染在ENKTCL的发生、发展中发挥着关键作用，并且与患者的预后和生存密切相关。除此之外，ENKTCL的发生也与某些相关基因的异常、信号通路的异常活化、肿瘤微环境相关。本文针对ENKTCL发病机制的新进展进行综述。 Extranodal natural killer/T-cell lymphoma, nasal type （ENKTCL） is a kind of highly aggressive non-Hodgkin lymphoma （NHL） with special epidemiological characteristics. The pathogenesis of ENKTCL is still unclear and the treatment meets great challenges until now. In recent years, many researchs showed that EB virus （EBV） infection played a key role in the occurrence and development of ENKTCL. In addition, certain genetic abnormalities, aberrant activation of signaling pathways and the tumor microenvironment were related to the pathogenesis of ENKTCL. This paper reviews new advance on the pathogenesis of ENKTCL.
作者 周佳楠 王松梅 陈波斌
机构地区 复旦大学附属华山医院血液科 复旦大学基础医学院医学实验教学中心分子生物学实验室
出处 《国际输血及血液学杂志》 CAS 2016年第5期380-384,共5页 International Journal of Blood Transfusion and Hematology
基金 国家自然科学基金面上项目（81470352） 上海市卫生计生委中医科研基础项目（2014JP003A）
关键词 EPSTEIN-BARR病毒感染 癌基因 基因 肿瘤抑制 淋巴瘤 结外NK/T细胞 Epstein-Barr virus infections Oncogenes Genes, tumor suppressor Lymphoma,extranodal NK-T-cell
分类号 R733.1 [医药卫生—肿瘤]
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参考文献36

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国际输血及血液学杂志
2016年 第5期

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