摘要
异基因造血干细胞移植（allo—HSCT）后患者的免疫重建与其移植结果密切相关。移植后B淋巴细胞重建是allo—HSCT后患者机体主动免疫重建的重要组成部分。移植物来源及组成、预处理方案、移植物抗宿主病（GVHD）的发生及其治疗均可影响allo—HSCT后患者的B淋巴细胞重建，而allo—HSCT后B淋巴细胞及其亚群的快速重建可降低GVHD的发生率。笔者就影响allo—HSCT后B淋巴细胞重建的因素及B淋巴细胞重建对移植结果的影响作一综述。
The clinical outcome after allogeneic hematopoietic stem cell transplantation （allo-HSCT） is closely related to the status of immune reconstitution. B lymphocyte reconstitution is one of the main part of the active immune reconstitution after allo-HSCT. The source and component of graft, conditioning regimen, graft-versus-host disease（GVHD） and its treatment are main factors affecting B lymphocyte reconstitution. On the other hand, rapid B lymphocyte reconstitution after allo-HSCT can reduce the occurrence of GVHD. Here the authors review B lymphocyte reconstitution and its influencing factors after allo-HSCT.
出处
《国际输血及血液学杂志》
CAS
2016年第5期399-404,共6页
International Journal of Blood Transfusion and Hematology
基金
安徽省科技厅科技计划项目（1301043028）
安徽省卫生计生委医学科研计划项目（13zc018）
关键词
B淋巴细胞
免疫
功能恢复
移植
B-lymphocytes
Immunity
Recovery of function
Transplantation
