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脐血移植后自然杀伤细胞重建的规律和特点

Research progress of regularity and characteristics of natural killer cell reconstitution after cord blood transplantation
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摘要 近年，脐血移植（UCBT）在治疗多种血液系统疾病方面展现了广阔的应用前景，其治疗白血病的远期疗效佳，同时移植后移植物抗宿主病（GVHD）的发生率及白血病复发率均较低，因而引起了研究者对UCBT后机体免疫重建的兴趣。人类自然杀伤（NK）细胞作为一种天然免疫细胞，在UCBT后免疫重建过程中扮演了重要的角色，本文就UCBT后NK细胞的重建规律和特点进行综述。 Umblical cord blood transplantation （UCBT） show broad prospects in the treatment of malignant and non-malignant hematological diseases with a good long-term curative effect. Incidence of graft-versus-host disease （GVHD） and recurrence rate of leukemia after UCBT were lower than those after bone marrow transplantation. Thus, it has aroused the interest of researchers on immune reconstitution after UCBT. Human natural killer （NK） cell is a kind of natural immune cells, which plays an important role after UCBT. In this article, the rules and characteristics of NK cell reconstruction after UCBT are reviewed.
作者 陈二玲 孙自敏
机构地区 安徽医科大学附属省立医院血液科
出处 《国际输血及血液学杂志》 CAS 2016年第5期424-427,共4页 International Journal of Blood Transfusion and Hematology
基金 国家自然科学基金项目（81470350）
关键词 脐血干细胞移植 免疫 杀伤细胞 天然 Cord blood stem cell transplantation Immunity Killer cells, natural
分类号 R457.7 [医药卫生—治疗学]
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参考文献36

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二级参考文献17

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国际输血及血液学杂志
2016年 第5期

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