细胞自噬的发生机制及中医药对其干预作用进展

Advance in mechanism of autophagy and its intervention by traditional Chinese medicine

概述细胞自噬的发生发展机制,并重点探讨细胞自噬与中医理论的相关性和中医药对其干预作用的研究进展。细胞自噬一般分为3类,细胞自噬形成过程包括诱导阶段、形成阶段、成熟降解阶段。目前研究发现细胞自噬与中医理论"气虚痰瘀""阴阳自合""肝主疏泄"等密切相关,且大量研究表明中医药对细胞自噬水平有调节作用。

This paper reviewed the mechanism of occurrence and development of autophagy, and mainly discussed on the correlation between autophagy and the theory of traditional Chinese medicine and the research progress of the intervention of traditional Chinese medicine on autophagy. Autophagy is generally divided into 3 categories, the process of autophagy formation includes the induction stage, the formation stage and the mature degradation stage. At present, research found that autophagy was closely related to the theory of traditional Chinese medicine, such as ＂Qi deficiency and phlegm stasis＂, ＂self-combination of Yin and Yang＂, ＂liver controlling conveyance and dispersion＂ and so on. And a large number of studies indicated that traditional Chinese medicine showed regulatory effect on the level of autophagy.