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乳腺癌易感基因突变相关研究进展 被引量：5

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摘要 乳腺癌（breast cancer,BRC）是女性最常见的恶性肿瘤之一。多数乳腺癌呈散发性,约5%-10%的乳腺癌具有遗传易患性,表现为家族聚集性,且发病多〈50岁。乳腺癌易感基因1（breast cancer susceptibility gene 1,BRCA-1）和BRCA2基因突变引起约60%的遗传性乳腺癌,且是遗传性乳腺癌-卵巢癌综合征（hereditary breast and ovarian cancer syndrome,HBOC）目前已知的唯一因素。
作者 倪姗姗 陈益定
机构地区 浙江大学医学院附属妇产科医院妇产科 浙江大学医学院附属第二医院肿瘤外科
出处 《实用肿瘤杂志》 CAS 2016年第5期405-409,共5页 Journal of Practical Oncology
基金 浙江省自然科学基金重点项目(LZ16H160002) 浙江省卫生高层次创新人才培养工程项目
关键词 乳腺肿瘤 基因 BRCA1 基因 BRCA2 突变 序列分析 疾病遗传易感性/遗传学 聚合酶链反应 危险
分类号 R737.9 [医药卫生—肿瘤]
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参考文献26

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二级参考文献42

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实用肿瘤杂志
2016年 第5期

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