Research progress of the role and mechanism of extracellular signal-regulated protein kinase 5(ERK5) pathway in pathological pain

ERK5信号通路在病理性疼痛中的作用及其机制的研究进展（英文）

Extracellular signal-regulated protein kinase 5 （ERK5）, also known as big mitogen-activated protein kinase 1 （MAPK1）, is an important member of ERK family, which is a subfamily of the large MAPK family. ERK5 is expressed in many tissues, including the dorsal root ganglion （DRG） neurons and the spinal cord. In this review, we focus on elaborating ERK5-associated pathway in pathological pain, in which the ERK5/CREB （cyclic adenosine monophos- phate （cAMP）-response element-binding protein） pathway plays a crucial role in the transduction of pain signal and contributes to pain hypersensitivity. ERK5 activation in the spinal dorsal horn occurs mainly in microglia. The activation of ERK5 can be mediated by N-methyI-D-aspartate （NMDA） receptors. We also elaborate the relationship between ERK5 activation and nerve growth factor-tyrosine kinase A （NGF-TrkA）, and the connection between ERK5 activation and brain-derived neurotrophic factor （BDNF） in pathological pain in detail.

细胞外信号调节蛋白激酶5(ERK5),也称大丝裂原活化蛋白激酶1,是ERK家族(MAPK大家族的一个亚家族)的一个重要成员。ERK5在背根神经节和脊髓中均有表达。本文着重阐述ERK5相关的信号通路在病理性疼痛中的作用:ERK5/CREB通路在疼痛信号的传递和痛觉过敏的形成中起重要作用;脊髓背角中ERK5的活化主要在小角质细胞;ERK5的活化可由NMDA受体介导。同时,我们细述了在病理性疼痛中,ERK5活化与NGF-TrkA和BDNF的关联。