不同方法治疗慢性化脓性骨髓炎的对照研究

A Comparative Study on Different Methods for Treatment of Chronic Pyogenic Osteomyelitis

目的:探讨慢性化脓性骨髓炎的不同方法治疗的临床对照研究。方法:入选我院2014年4月至2015年3月收治的慢性化脓性骨髓炎患者80例,按照入院先后顺序随机分为研究组、对照组,每组40例,研究组进行负压封闭引流术与五味消毒饮加味法联合治疗,对照组进行单纯负压封闭引流术治疗,评估比较两组的临床效果。结果:研究组的有效率是95.0%、对照组的有效率是57.5%,两组比较差异有统计学意义(P<0.05);研究组治疗后发生局部贫血、低蛋白血症、全身淀粉样变、肿胀、皮肤温度升高、病灶疼痛等不良反应情况显著低于对照组,差异有统计学意义(P<0.05);研究组的应用抗生素时间、发热持续时间、疼痛持续时间、住院时间等临床指标显著优于对照组,差异有统计学意义(P<0.05)。结论:慢性化脓性骨髓炎患者进行负压封闭引流术与五味消毒饮加味联合疗法,可促进病情迅速康复,降低不良反应的发生情况,临床效果确切,值得临床推广。

Objective： To investigate the clinical study on different methods for treatment of chronic suppurative osteomyelitis. Methods： 80 patients with chronic suppurative osteomyelitis admitted in our hospital from April 2012 to April 2015 were selected and were divided into study group and control group aecording to the random number table method, 40 cases in each group. The patients in research group were treated with vacuum sealing drainage and five flavor disinfection drink. The patients in control group were treated with vac- uum sealing drainage. The clinical effects of the two groups were evaluated. Results： The clinical effective rate of the study group was 95.0% and the control group was 57.5%. The difference between the two groups was statistically significant （P〈0.05）. The incidence of adverse reactions （local anemia, low protein, systemic amyloidosis, swelling, elevated skin temperature, and focal pain ） was significantly lower than that of the con- trol group （P〈0.05）. The clinical indicators （duratin of using antibiotic, fever duration, duration of pain, length of stay ） of the study group were significantly better than the control group （ P 〈 0.05 ）. Conclusion： negative pressure closed drainage operation combined wuweixiaodu Decoction Jiawei therapy for patients with chronic suppurative osteomyelitis can promote rapid disease rehabilitation, reduce the incidence of adverse re- actions, clinical curative effect, worthy of clinical promotion.