清亮饮治疗家兔玻璃体积血影响实验研究

Experimental Study on Qing Liang Yin Treating Rabbits Vitreous Hemorrhage

目的:观察清亮饮对家兔玻璃体积血的影响,探讨其可能的机制。方法:随机将30只家兔按照性别分为正常组、模型组和治疗组。正常组不给予任何干预措施,模型组和治疗组给予自身血液推注造模,24h后观察造模是否成功,造模成功后,治疗组给予4.9g·kg-1·d-1清亮饮原药治疗,煎煮、浓缩后灌胃,治疗8周后,观察眼底可见度并进行分级评分,同时采用Elisa法检测玻璃体液中IL-6、TNF-α含量。结果:与模型组比较,治疗组家兔眼底可见度明显改善(P<0.05),玻璃液中TNF-α、IL-6的水平显著降低(P<0.05,P<0.01)。结论:清亮饮对治疗家兔玻璃体积血具有显著作用,其机制可能与调节玻璃体液中IL-6、TNF-α水平有关,

Objective： To observe the effect of qing liang yin for the rabbit vitreous hemorrhage and explore its possible mechanism. Methods： 30 rabbits were randomly divided into groups according to gender, model group and treatment group. Normal group was not given any intervention, the model group and the treat- ment group received autologous blood injection modeling model is successful, the treatment group received 4.9g cook and concentrated garage, 8 weeks after treatment, 24h after the observation modeling success, after the / kg / d drink clear the original drug therapy, fried observation fundus visibility and grading, while using Elisa assay vitreous humor IL-6, TNF-α content. Results： Compared with model group, the treatment group rabbits fundus visibility improved significantly （P 〈0.05）, the molten glass TNF-α, IL-6 levels weresignifi- cantly reduced （P 〈0.05, P 〈0.01 ）. Conclusion： Qing liang yin has a significant effect for the treatment of vitreous hemorrhage in rabbits, which may be related to regulating the vitreous humor IL-6, TNF-α levels related.